منابع مشابه
Myocardial contraction-relaxation coupling.
Since the pioneering work of Henry Pickering Bowditch in the late 1800s to early 1900s, cardiac muscle contraction has remained an intensely studied topic for several reasons. The heart is located centrally in our body, and its pumping motion demands the attention of the observer. The contraction of the heart encompasses a complex interplay of mechanical, chemical, and electrical properties, an...
متن کامل54TH BOWDITCH LECTURE Myocardial contraction-relaxation coupling
Janssen PM. Myocardial contraction-relaxation coupling. Am J Physiol Heart Circ Physiol 299: H1741–H1749, 2010. First published September 17, 2010; doi:10.1152/ajpheart.00759.2010.—Since the pioneering work of Henry Pickering Bowditch in the late 1800s to early 1900s, cardiac muscle contraction has remained an intensely studied topic for several reasons. The heart is located centrally in our bo...
متن کاملContraction-relaxation coupling: determination of the onset of diastole.
Left ventricular relaxation is dependent on afterload conditions during systole. An abrupt increase in afterload while the ventricle is actively contracting prolongs the duration of systole. An increase in afterload during ventricular relaxation shortens the duration of systole. Therefore, we hypothesized that the point during systole when an abrupt increase in afterload had no effect on the du...
متن کاملMyocardial Oxygen Consumption during Ventricular Contraction and Relaxation.
• As early as 1915 it was known that an increase in systolic pressure is accompanied by a greater myocardial oxygen cost than a proportionate increase in stroke volume. Recent investigators have related myocardial oxygen consumption to the product of the mean systolic pressure and the heart rate, or to the integral of systolic pressure in time. In the isovolumetrically contracting ventricle, my...
متن کاملUncoupling protein-2 modulates myocardial excitation-contraction coupling.
RATIONALE Uncoupling protein (UCP)2 is a mitochondrial inner membrane protein that is expressed in mammalian myocardium under normal conditions and upregulated in pathological states such as heart failure. UCP2 is thought to protect cardiomyocytes against oxidative stress by dissipating the mitochondrial proton gradient and mitochondrial membrane potential (DeltaPsi(m)), thereby reducing mitoch...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2010
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00759.2010